Oncological diseases of the cardiovascular System

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Oncological diseases of the cardiovascular system: epidemiology, pathogenesis and clinical implications Oncological diseases affecting the circulatory System, represent a heterogeneous group of diseases that include both primary tumors of the heart as well as secondary findings by metastases or treatment effects. Although such disorders are on the whole rare, you will have due to their potentially life-threatening complications of high clinical relevance. Epidemiology Primary cardiac tumors are rare and approximately 0.001 make–0.3% of all began the autopsy cases. Most of these tumors are benign; of these, approximately 50% are Myxomas, followed by lipomas, Papillomas and fibromas. Malignant heart tumors, especially sarcomas (e.g., Angiosarkome, Rhabdomyosarcoma), are significantly more rare and account for approximately 25% of primary cardiac tumors. Metastases in the area of the cardiovascular system, however, are significantly more common than primary tumors. They occur in about 10-15% of patients with systemic malignancies. Common primary tumors of the heart metastases are lung cancer, breast cancer, melanoma, and lymphoma. Pathogenesis and tumor types Primary benign tumors: Myxomas (usually in the left atrium localized) can cause valves to emboli, stenosis or insufficiency of the heart. Lipomas and fibromas are often asympomatisch, however, can cause a larger volume of mechanical complications. Malignant Tumors Primary: Angiosarkome are the most common Form of cardiac sarcomas and show an aggressive growth and early metastasis. Mesothelioma of the Pericardium are rare, however, effusions often to Pericardial and tamponade. Metastases: The most common localizations of the pericardium, the heart surface and, more rarely, the myocardial tissue. Pericardial metastases often lead to exudative perikardit halides, and pericardial tamponade. Clinical Symptoms Thief pendent of the tumor localization and size of the clinical symptoms vary greatly: Pericardial infection: pericarditis, Pericardial effusion, Tamponade (pressure, jugular vein congestion, Pulsus paradoxus). Atrial infestation (e.g., Myxoma): embolism (cerebral, or peripheral), heart valve insufficiency, dizziness, exertional dyspnoea. Ventricular Tumors: Congestive Heart Failure, Arrhythmias, Discharge Behind Containers. Coronary arteries metastases: Angina pectoris, myocardial infarction. Diagnostics The diagnostics includes: Echocardiography (TTE/TEE): first choice for the detection of tumors, and pericardial effusions. Magnetic resonance imaging (MRI): excellent tissue differentiation, and localization. Computer tomography (CT): for the assessment of Calcification and extra-cardiac Findings. PET‑CT: for the differentiation of benign and malignant processes and to search for the primary tumor. Biopsy: in unclear cases, the histological backup. Therapy Therapeutic strategies depend on the type of tumor: Surgical resection: a method of choice for inoperable benign tumors, and various sarcomas. Chemotherapy and radiation therapy for inoperable or metastatic malignancies. Palliative measures: pericardial window, Perikardzentese Aden in Tampon. Forecast The prognosis varies greatly: Benign tumors after complete resection have a favorable prognosis. Malignant tumors have a poor prognosis, with a media show survival time of 6-12 months after diagnosis. Summary Oncological diseases of the cardiovascular system are rare, but require early diagnosis and interdisciplinary treatment. Advances in imaging and surgical technique have improved the prognosis in an individual patient groups. Nevertheless, the therapy of malignant cardiac and vascular tumors is a challenge for medicine.

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Oncological diseases of the cardiovascular System

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Oncological diseases of the cardiovascular System. 15 prevention of cardiovascular diseases.

Differences between the first and second degrees of hypertension The arterial hypertension, also called high blood pressure is known, is divided into different levels of Degree, the Severity of the disease adequately, and the therapeutic measures aimed adjust to assess. The difference between the first (grade I) and the second grade (grade II) of hypertension is the blood pressure, the risk profile and the required treatment strategies. At the first degree of hypertension (grade I) are found to have systolic blood pressure between 140 and 159 mmHg and diastolic values between 90 and 99 mmHg. In many cases, this stage is asymptomatic, which complicates the diagnosis. The treatment often begins with non‑drug measures: Change in diet (reduction of salt and fat intake), regular physical activity, Weight reduction in Overweight, Waiver of nicotine and reduction of alcohol consumption. The second degree of hypertension (grade II) is characterized by significantly elevated blood pressure: systolic 160-179 mmHg, diastolic 100-109 mmHg. At this stage, a significantly increased risk for organ damage, particularly to the heart, kidneys and blood vessels. Typical symptoms can be the following: Headache, Dizziness, Blurred vision, Chest pain. A significant difference in the first degree is that in the case of grade II in General, a drug therapy immediately instituted, it must be. Treatment often includes combinations of various antihypertensive agents, such as: ACE inhibitors, Calcium channel blocker Diuretics, Beta-blockers. In addition, risk factors play a more important role in the assessment of the prognosis. In the case of grade II comorbidities often occur, such as: Diabetes mellitus, Dyslipidemia, obesity. In summary, we can say that the second degree of hypertension is characterized in comparison to the first degree, higher blood pressure values, a significantly increased risk of complications and the need for early drug treatment. Early diagnosis and adequate therapy are crucial to prevent long-term damage to vital organs.